Current methods for biomarker discovery and target identification in immuno-oncology rely on static snapshots of tumor immunity.To thoroughly characterize the temporal nature of antitumor immune responses, we developed a 34-parameter spectral flow cytometry panel and performed high-throughput analyses in critical contexts.We leveraged two distinct
Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias
BackgroundHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI models, representing a major peperomia double duty hurdle to translation.Our group previously
The tip of the iceberg: a giant pelvic atypical lipoma presenting as a sciatic hernia
Abstract Background This case report highlights two unusual surgical phenomena: lipoma-like well-differentiated liposarcomas and sciatic hernias.It illustrates the need to nitrile gloves in a bucket be aware that hernias may not always simply contain intra-abdominal viscera.Case presentation A 36 year old woman presented with an expanding, yet redu
Channelized active noise elimination (CANE) for suppressing quantization noise in bitstream modulated transmitter (BMT)
Abstract Bitstream modulated transmitters may offer improved power efficiency and getpureroutine.com linearity simultaneously in RF power amplifiers.Several modulation techniques including envelop delta-sigma modulation and envelope pulse width modulation have been applied.The out-of-band quantization noise associated with these modulations may be